Novel positive regulatory role for the SPL6 transcription factor in the N TIR-NB-LRR receptor-mediated plant innate immunity.

Novel positive regulatory role for the SPL6 transcription factor in the N TIR-NB-LRR receptor-mediated plant innate immunity.

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Following the recognition of pathogen-encoded effectors, trailmaster challenger 200x plant TIR-NB-LRR immune receptors induce defense signaling by a largely unknown mechanism.We identify a novel and conserved role for the SQUAMOSA PROMOTER BINDING PROTEIN (SBP)-domain transcription factor SPL6 in enabling the activation of the defense transcriptome following its association with a nuclear-localized immune receptor.During an active immune response, the Nicotiana TIR-NB-LRR N immune receptor associates with NbSPL6 within distinct nuclear compartments.NbSPL6 is essential for the N-mediated resistance to Tobacco mosaic virus.Similarly, the presumed Arabidopsis ortholog AtSPL6 is required for the resistance mediated by the TIR-NB-LRR RPS4 against Pseudomonas syringae carrying the avrRps4 effector.

Transcriptome analysis indicates that AtSPL6 positively regulates a subset of defense genes.A pathogen-activated nuclear-localized TIR-NB-LRR like N can therefore arcade smokey the bear belt regulate defense genes through SPL6 in a mechanism analogous to the induction of MHC genes by mammalian immune receptors like CIITA and NLRC5.